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Abstract #2849

Quantification of cerebrospinal fluid flow through the cerebral aqueduct using 7T MRI

JM Spijkerman1, JCW Siero1,2, LJ Geurts1, MJ Donahue3, J Hendrikse1, PR Luijten1, and JJM Zwanenburg1

1Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2Spinoza Center for Neuroimaging, Amsterdam, Netherlands, 3Department of Radiology, Vanderbilt University Medical Center, Nashville, TN, United States

In this work the feasibility of recording high spatial resolution quantitative flow (Qflow) measurements in the cerebral aqueduct at 7T was investigated. Five volunteers were scanned, two encoding velocities (venc) were used: 5 and 13 cm/s. Repeated measurements were performed (venc=5cm/s: n=4; venc=13 cm/s: n=5). Mean net CSF flow through the aqueduct (directed towards the spine) was (mean±std) 332±128 ml/day for venc=5cm/s and 441±149 ml/day for venc=13cm/s, which is in accordance with values found in literature. Reasonable reproducibility of the measurements was found.

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