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Abstract #2891

Improved sensitivity for rectal cancer differentiation by T2*-correction in DCE-MRI

Endre Grøvik1, Kathrine Røe Redalen2, Tryggve Holck Storås1, Anne Negård3, Stein Harald Holmedal3, Anne Hansen Ree3, Sebastian Meltzer3, Atle Bjørnerud1, and Kjell-Inge Gjesdal4

1Oslo University Hospital, Oslo, Norway, 2Akershus University Hospital, Norway, 3Akershus University Hospital, Lørenskog, Norway, 4Sunnmøre MR-klinikk, Ålesund, Norway

Quantitative pharmacokinetic analysis from DCE-MRI often neglects CA-induced T2*-effect when converting signal intensity (SI) changes in tissue to CA concentration. The acquired signal may thus be significantly affected by T2* signal attenuation, which in turn results in errors in the DCE-derived parameters. This work utilized a dynamic multi-echo acquisition for extrapolation back to TE=0, thus providing both T2*-corrected and uncorrected measurements of DR1, and investigates the how the correction for T2*-attenuation effects may affect the sensitivity for rectal cancer differentiation by DCE-MRI. The T2*-corrected data showed improved differentiation of rectal cancer.

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