Meeting Banner
Abstract #2890

Quantitative evaluation of the effect of temporal resolution and acquisition duration on the accuracy of DCE-MRI measurements in a prostate phantom

Silvin P. Knight1, Jacinta E. Browne2, James F. Meaney1, and Andrew J. Fagan1

1School of Medicine / National Centre for Advanced Medical Imaging (CAMI), Trinity College University of Dublin / St James's Hospital, Dublin 8, Ireland, 2School of Physics & Medical Ultrasound Physics and Technology Group, Centre of Industrial Engineering Optics, FOCAS, Dublin Institute of Technology, Dublin 8, Ireland

A novel anthropomorphic prostate phantom test device was used to investigate the effects of temporal resolution (Tres) and acquisition duration (AD) on the accuracy of contrast time-intensity curves measured using dynamic contrast-enhanced MRI. When quantitatively compared to ground truth values, large errors in derived pharmacokinetic (PK) parameters (up to 230%) were found for Tres values > 8.1 s and AD values < 360 s. The data demonstrate the critical and sensitive dependence of the accuracy of measured PK output parameter values on the acquisition protocol used, while such phantom studies can help identify optimal acquisition parameters for DCE-MRI scans

This abstract and the presentation materials are available to members only; a login is required.

Join Here