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Abstract #2900

DDC and α estimates from the stretched exponential model are more robust to variations in b-value selection than ADC estimates, in a cohort of 42 cervical tumours

Jessica M Winfield1,2, Nandita M deSouza1,2, Veronica A Morgan1,2, David J Collins1,2, and Matthew R Orton1,2

1Cancer Research UK Cancer Imaging Centre, The Institute of Cancer Research, London, United Kingdom, 2MRI Unit, The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom

The influence of b-value selection on fitted parameters from the stretched exponential model (distributed diffusion coefficient DDC, and ‘stretching parameter’ α) and mono-exponential model (apparent diffusion coefficient ADC) was investigated in a cohort of 42 patients with cervical tumours. Diffusion-weighted images images were acquired using 9 b-values between 0 and 800smm-2, and fitted voxel-by-voxel using all b-values (0 to 800smm-2) and b-values n-to-800smm-2 (where n is 20,40,60,80,100, or 300smm-2). ADC estimates are highly sensitive to b-value selection, with reduction in ADC when low b-values are excluded, whereas DDC and α are more robust to differences in b-value selection.

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