Abstract #2901

Combined analysis of ten DW-MRI studies demonstrates excellent repeatability of apparent diffusion coefficient estimates in extra-cranial soft-tissue tumours

Jessica M Winfield^1,2, Nina Tunariu^1,2, Mihaela Rata^1,2, Keiko Miyazaki^1,2, Neil P Jerome^1,2, Michael Germuska^1,2,3, Matthew D Blackledge^1,2, David J Collins^1,2, Johann S de Bono^4,5, Timothy A Yap^4,5, Nandita M deSouza^1,2, Simon J Doran^1,2, Dow-Mu Koh^1,2, Martin O Leach^1,2, Christina Messiou^1,2, and Matthew R Orton^1,2

¹Cancer Research UK Cancer Imaging Centre, The Institute of Cancer Research, London, United Kingdom, ²MRI Unit, The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom, ³Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, ⁴Drug Development Unit, The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom, ⁵Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

Repeatability of ADC estimates from ten diffusion-weighted MRI studies in extra-cranial soft tissues (nine patient studies and one healthy volunteer study, with a total of 111 subjects) were analysed in combination using the Radiological Society of North America (RSNA) Quantitative Imaging Biomarkers Alliance (QIBA) framework for assessment of technical performance of imaging biomarkers, in order to investigate factors affecting ADC repeatability. Coefficient of variation was between 2 and 7% for all studies, with no marked differences between imaging protocols or study populations, and better repeatability in large tumours compared with smaller tumours, indicating that ADC is a robust imaging metric with excellent repeatability in extra-cranial soft-tissue tumours.

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