We evaluated histogram analysis of ADC maps to differentiate benign from malignant solid paediatric tumours in children and distinguish tumour type. Fifty children (38 malignant, 12 benign tumours) were imaged using multi-b value diffusion-weighted MRI at diagnosis. Whole tumour regions-of-interest (ROIs) were drawn, ADC histograms constructed, and median, 2nd to 98th percentile ADC values, skewness, kurtosis and entropy calculated. ADC histogram parameters were significantly different between malignant and benign lesions, with skewness and kurtosis being the most predictive of malignancy.
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