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Abstract #2911

ADC and D from diffusion-weighted MRI correlate with histopathological assessment of nuclear-to-stromal ratio, and histology confirms Dixon fat fraction in retroperitoneal sarcomas

Jessica M Winfield1,2, Khin Thway3, Aisha Miah4, Dirk Strauss5, David J Collins1,2, Martin O Leach1,2, Nandita M deSouza1,2, Sharon L Giles1,2, and Christina Messiou1,2

1Cancer Research UK Cancer Imaging Centre, The Institute of Cancer Research, London, United Kingdom, 2MRI Unit, The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom, 3Department of Histopathology, The Royal Marsden NHS Foundation Trust, London, United Kingdom, 4Department of Radiotherapy, The Royal Marsden NHS Foundation Trust, London, United Kingdom, 5Department of Surgery, The Royal Marsden NHS Foundation Trust, London, United Kingdom

Soft-tissue sarcomas are often highly heterogeneous tumours. Clinical trials of non-surgical treatments, for example combined radiotherapy and systemic agents, require non-invasive methods for response assessment. Quantitative MRI provides non-invasive response assessment of the whole tumour volume, but metrics require validation against histopathology. In this study, 26 patients with retroperitoneal sarcoma were imaged prior to surgery, with written consent, as part of a prospective single-centre study. Diffusion-weighted MRI parameters (ADC, and D from IVIM) showed correlation with nuclear-to-stromal ratio, and were also related to stroma type and stroma grade. Dixon-derived fat fraction correlated strongly with histopathological assessment of fat fraction.

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