Abstract #2912

Label-free CEST MRI detection of albumin and albumin-based nanoparticles

Yuguo Li^1,2, Dexiang Liu³, Jiadi Xu^1,2, Peter C.M. van Zijl^1,2, Shibin Zhou⁴, and Guanshu Liu^1,2

¹F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ²Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Radiology, Guangzhou Panyu Central Hospital, ⁴Ludwig Center, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Albumin is emerging as one of the most attractive drug carriers for the targeted delivery of therapeutic peptides and drugs. Herein, we developed a label-free MRI approach for monitoring albumin-based drug delivery systems by directly utilizing the inherent CEST signal of albumin. Our in vitro study showed that both human serum albumin (HSA) and albumin-based nanoparticle Nab-paclitaxel (Abraxane) could generate a strong CEST signal at ~2 ppm. Using this inherent CEST signal, we successfully demonstrated the label-free CEST MRI detection of the tumor uptake and distribution HSA and Nab-paclitaxel in a xenograft mouse model.

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