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Abstract #2917

Providing improved reliability of plasma volume fraction estimates for monitoring anti-angiogenic effects in liver metastases with DCE-MRI

Mihaela Rata1, Khurum Khan1, David Collins1, Nina Tunariu1, Dow-Mu Koh1, James d'Arcy1, Maria Bali1, Ian Chau1, Nicola Valeri1, David Cunningham1, Martin O Leach1, and Matthew Orton1

1CR-UK Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden Hospital, London, United Kingdom

Pharmacokinetic modelling of DCE-MRI data allows characterisation of tumour response to anti-angiogenic therapies by estimating the volume transfer constant Ktrans and the plasma volume fraction Vp. This work assesses the impact on Ktrans and Vp of treatment changes in an early clinical trial cohort by comparing 4 models: Kety, extended Kety (with two lower limits on Vp), and a new model with Vp proportional to Ktrans. When Ktrans is the endpoint of interest, use of the Kety model is sufficient to depict cohort response. If Vp is also of interest, the new model improves the significance of Vp treatment effects.

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