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Abstract #2920

Combining DW- and DCE-MRI for treatment response assessment in patients with esophageal cancer undergoing neoadjuvant chemoradiotherapy

Sophie E. Heethuis1, Lucas Goense1,2, Peter S.N. van Rossum1,2, Alicia S. Borggreve1,2, Stella Mook1, Francine E. Voncken3, Richard van Hillegersberg2, Jelle P. Ruurda2, Gert J. Meijer1, Jan J.W. Lagendijk1, and Astrid L.H.M.W. van Lier1

1Department of Radiotherapy, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Surgery, University Medical Center Utrecht, Utrecht, Netherlands, 3Department of Radiotherapy, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam

Neoadjuvant chemoradiotherapy prior to surgery is often used for treatment of patients with esophageal cancer. Potential benefit could be gained developing a patient tailored treatment, especially for the 29% of the patients who show a pathologic complete response. In this prospective multicenter study it was investigated whether combining DCE- and DW-MRI, which both showed potential for response prediction in previous studies, yields complementary information. It was found that the combination of DCE- and DW-MRI can increase the predictive values and reaches higher ROCAUC.

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