Abstract #2919

In vivo OE-MRI quantification and mapping of response to hypoxia modifying drugs Banoxantrone and Atovaquone in Calu6 xenografts

Ross A Little¹, Victoria Tessyman², Muhammad Babur², Susan Cheung¹, Yvonne Watson¹, Roben Gieling², Katherine G Finegan², Thomas M Ashton³, Geoff JM Parker^1,4, W Gillies Mckenna³, Geoffrey Higgins³, Kaye J Williams^2,5, and James PB O'Connor^5,6

¹Centre for Imaging Sciences, University of Manchester, Manchester, United Kingdom, ²Manchester Pharmacy School, University of Manchester, Manchester, United Kingdom, ³CRUK/MRC Oxford Institute for Radiation Oncology and Biology, University of Oxford, Oxford, United Kingdom, ⁴Bioxydyn Ltd, Manchester, United Kingdom, ⁵Institute of Cancer Sciences, University of Manchester, Manchester, United Kingdom, ⁶Department of Radiology, The Christie NHS Foundation Trust, Manchester, United Kingdom

Oxygen-enhanced MRI (OE-MRI) has shown promise as a technique for quantifying and spatially mapping tumour hypoxia. Here we report the first evidence that OE-MRI signals in perfused tumour can non-invasively track therapy-induced changes in hypoxia in vivo in a tumour model. We show that OE-MRI detects (1) reduction in hypoxia and increase in necrosis induced by the hypoxia-activated cytotoxic prodrug Banoxantrone; and (2) reduction in hypoxia and increase in well oxygenated tumour induced by Atovaquone due to increased oxygen availability. These data support first-in-man use of OE-MRI biomarkers in clinical trials of hypoxia-modifying agents.

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