Meeting Banner
Abstract #2922

MRI Efficacy Evaluation of AvastinTM in Combination Temozolomide Therapy using GL261 Tumor Bearing Mice

Min-Kyoung Kang1, Sang-Woo Kim1, Ig-Jun Cho1, Joo-Young Kim1, Zhi Fang1, Byung-Hwa Hyun1, and Jae-Jun Lee*1

1Laboratory Animal Center, Osong Medical Innovation Foundation, Cheongju, Korea, Republic of

The aim of this study was to evaluate of the drug efficacy used by MRI. A mouse were randomly divided into the control and therapy groups for treatment. MRI were performed to compare with two groups and significant differences were observed in the two groups. The volume transfer constant (Ktrans), flux rate constant (kep) and contrast agent (Gd-DOTA-RGD) enhancement were decreased in the therapy group. Apparent diffusion coefficient (ADC) was lower in the control group. Furthermore, histopathologic assessments were in accord with MRI. Based on these results, efficacy evaluation used by MRI can be helped the development of new bio-drug.

This abstract and the presentation materials are available to members only; a login is required.

Join Here