Abstract #2923

Estimation of Contributions to Z-Spectra from CEST and Magnetization Transfer Contrast from Active and Necrotic/Apoptotic Regions of MDA Tumour Xenografts

Wilfred W Lam¹, Jonathan H Klein^1,2,3, Farah Hussein², Christine Tarapacki², Gregory J Czarnota^1,2,3,4, and Greg J Stanisz^1,3,5

¹Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ²Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ³Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁴Radiation Oncology, University of Toronto, Toronto, ON, Canada, ⁵Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Lublin, Poland

Chemical exchange saturation transfer (CEST) MR imaging has been demonstrated to be able to differentiate active from necrotic/apoptotic regions in MDA tumour xenografts. However, the Z-spectrum reflects not only CEST from dissolved proteins, but also contributions from water saturation and magnetization transfer contrast from semisolid macromolecules. We estimated their individual effect sizes and calculated which significantly contribute to the difference in Z-spectrum amplitude between the two tumour regions. The difference in Z-spectrum amplitude between active and necrotic/apoptotic regions in MDA tumour xenografts is due to the CEST effect with minimal contribution from magnetization transfer contrast and direct water saturation.

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