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Abstract #2925

Tumor Progression Monitoring with Hyperpolarized 13C Exchange Spectroscopy in Transgenic Adenocarcinoma of Mouse Prostate Treated with Androgen Deprivation Therapy

Zihan Zhu1,2, Robert Bok1, Hsin-Yu Chen1,2, John Kurhanewicz1, and Daniel B Vigneron1

1Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2UC Berkeley-UCSF Graduate Program in Bioengineering, UC Berkeley and UCSF, San Francisco, CA, United States

Hyperpolarized 13C MR imaging provides valuable enzyme-kinetic information for investigating disease metabolism. In this work, a new exchange spectroscopic imaging method was applied to a preclinical cancer treatment study and the metabolic information provided by this new method agreed with and proved additional quantitative kinetic metrics over traditional Response Evaluation Criteria in Solid Tumors (RECIST) measures.

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