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Abstract #2926

In vivo follow-up of colorectal cancer on mice model using endoluminal MRI

Hugo Dorez1, Raphaël Sablong1, Hélène Ratiney1, Laurence Canaple2, Hervé Saint-Jalmes3, Sophie Gaillard1, Driffa Moussata1,4, and Olivier Beuf1

1Univ Lyon, INSA‐Lyon, Université Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1206, Lyon, France, 2Institut de Génomique Fonctionnelle de Lyon, Université de Lyon 1, UMR 5242 CNRS, Ecole Normale Supérieure de Lyon, Lyon, France, 3LTSI; INSERM U642; Université Rennes 1, Rennes, France, 4Hôpital Régional Universitaire de Tours - Service hépato-gastroentérologie, Tours, France

For 6 months, 32 mice, chemically treated to induce colorectal cancer, were followed with endoluminal MRI using dedicated endorectal coils. Based on high spatial resolution T1-weigthed images and T1-maps, quantified parameters (colon wall thickness and T1 relaxation time) were measured at each stage of the pathology from healthy tissues to cancer through inflammation. The colon wall thickness was found to be reliable in assessing early stages of the pathology (inflammation from infiltration), where the intrinsic contrast T1 time parameter was reliable for discerning infiltration from tumors. The two biomarkers provide complementary information in the characterization and staging of colorectal cancer.

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