Pancreatic ductal adenocarcinoma (PDAC) is one of the most common forms of lethal human cancers with poor prognosis. Diagnosis is made usually late in tumor development. There is a dire need to develop sensitive non-invasive biomarkers to diagnose and monitor tumor progression and its associated pathological features. We propose to use multi-parametric MRI (mpMRI) to monitor tumor progression in a genetically engineered KPC mouse model that recapitulates human PDAC. Using mpMRI, we demonstrate that there is a significant correlation between increase in pancreatic tumor volume, Magnetization transfer ratio (MTR), apparent diffusion coefficient (ADC), and chemical exchange saturation transfer (CEST) imaging.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords