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Abstract #2938

31P MR spectroscopy of peripheral artery occlusive disease patients with and without diabetes

Petr Sedivy1,2, Miloslav Drobny1,2, Monika Dezortova1, Karel Roztocil3, Andrea Nemcova4, Vit Herynek1, Robert Bem4, Helena Cermakova3, Jan Peregrin5, and Milan Hajek1

1MR-unit, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 2First Faculty of Medicine, Charles University, Prague, Czech Republic, 3Transplant Surgery Dept., Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 4Dept. Diabetology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 5Dept. Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

Reduced blood supply limits the oxidative muscle metabolism and causes acidosis due to anaerobic glycolysis. Similar results were found in patients with peripheral artery occlusive disease (PAOD) in which chronic ischemia causes claudication and restricts walking distance. 31P MR spectroscopy of calf muscles of healthy controls and patients show that PAOD significantly influences muscular metabolism which is reflected in dynamic parameters of PAOD patients. The effect of diabetes is significantly pronounced in diabetic PAOD patients at rest compared to controls and PAOD patients without diabetes.

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