Reduced blood supply limits the oxidative muscle metabolism and causes acidosis due to anaerobic glycolysis. Similar results were found in patients with peripheral artery occlusive disease (PAOD) in which chronic ischemia causes claudication and restricts walking distance. 31P MR spectroscopy of calf muscles of healthy controls and patients show that PAOD significantly influences muscular metabolism which is reflected in dynamic parameters of PAOD patients. The effect of diabetes is significantly pronounced in diabetic PAOD patients at rest compared to controls and PAOD patients without diabetes.
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