Abstract #2937

Chronic liver disease in developing brain: an in vivo longitudinal and multiparametric study using 31P MRS, 31P Magnetization transfer and 1H MRS

Veronika Rackayova¹, Vladimir Mlynarik², and Cristina Cudalbu³

¹Laboratory for Functional and Metabolic Imaging, EPFL, Lausanne, Switzerland, ²High Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, ³Centre d’Imagerie Biomedicale (CIBM), EPFL, Lausanne, Switzerland

Chronic liver disease (CLD) induces irreversible brain alterations, especially in children, probably linked with oxidative stress and energy metabolism perturbations. Our aim was to use combination of NOE enhanced and ¹H-decoupled ³¹P-MRS, ³¹P-saturation transfer experiment (to estimate mitochondrial creatine kinase rate) and ¹H-MRS to study the effect of CLD on developing brain. Our results show significantly reduced k_ATP→PCr and fluctuating NAD⁺/NADH ratio indicating perturbation in mitochondrial function, possibly induced by oxidative stress. In addition, altered phospholipid metabolism was observed.

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