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Abstract #2937

Chronic liver disease in developing brain: an in vivo longitudinal and multiparametric study using 31P MRS, 31P Magnetization transfer and 1H MRS

Veronika Rackayova1, Vladimir Mlynarik2, and Cristina Cudalbu3

1Laboratory for Functional and Metabolic Imaging, EPFL, Lausanne, Switzerland, 2High Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, 3Centre d’Imagerie Biomedicale (CIBM), EPFL, Lausanne, Switzerland

Chronic liver disease (CLD) induces irreversible brain alterations, especially in children, probably linked with oxidative stress and energy metabolism perturbations. Our aim was to use combination of NOE enhanced and 1H-decoupled 31P-MRS, 31P-saturation transfer experiment (to estimate mitochondrial creatine kinase rate) and 1H-MRS to study the effect of CLD on developing brain. Our results show significantly reduced kATP→PCr and fluctuating NAD+/NADH ratio indicating perturbation in mitochondrial function, possibly induced by oxidative stress. In addition, altered phospholipid metabolism was observed.

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