Abstract #2936

In vivo 31P spectroscopy of ATP levels during a fructose challenge in the liver at 7T

Irene M.L. van Kalleveen^1,2, Jurgen H. Runge^1,3, Wybe J.M. van der Kemp⁴, Debra S. Rivera^1,2,5, Jaap Stoker¹, Dennis W.J. Klomp⁴, and Aart J. Nederveen¹

¹Radiology, Academic Medical Center, Amsterdam, Netherlands, ²Spinoza Centre, Amsterdam, Netherlands, ³Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, ⁴Radiology, UMC Utrecht, Utrecht, Netherlands, ⁵MR Coils, Zaltbommel, Netherlands

The standard evaluation of detecting liver parenchyma is invasive liver biopsy, while MRS is a non-invasive measurement to monitor metabolites. Using ³¹P spectroscopy it is possible to follow metabolic changes in the liver and the functionality of the liver during fructose uptake by measuring ATP levels. Going to ultra-high field strength, we are more sensitive to ATP levels and are able to use more localized MRS sequences (e.g. 3D CSI). We have shown we are able to monitor ATP levels during fructose uptake in vivo in the liver at 7T and see a decrease in ATP levels during the uptake.

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