Ferumoxytol is a licensed carbohydrate-coated, superparamagnetic iron oxide nanoparticle indicated in the treatment of anaemia. We show that, in contrast to other agents, it predominantly reduces T2, is confined to the blood pool for >1 hour post administration, and therefore could improve the efficiency of saturation pulses that aim to remove the 2,3-diphosphoglycerate signal from blood. This proof-of-principle study shows that Ferumoxytol could enable inorganic phosphate detection in vivo, and hence the determination of pH.
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