Dissolution Dynamic Nuclear Polarized NMR (dDNP NMR) is a promising new tool for assessing metabolism in vivo. The signals of the hyperpolarized substrate and its downstream metabolites are usually detected by direct 13C observation. Here we demonstrate an effective way to repetitively transfer hyperpolarization via indirect couplings from [1-13C] to [3,3,3-1H3] in [1-13C] lactate formed from hyperpolarized [1-13C] pyruvate. The changes in the hyperpolarized [3,3,3-1H3] lactate peak were fitted to a kinetic model. The method sets the stage for dynamic hyperpolarized 1H imaging.
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