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Abstract #2943

Analyzing Reaction Dynamics With Hyperpolarized 13C-NMR

Nicholas Drachman1, Stephen Kadlecek1, and Rahim Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States

In this study we use hyperpolarized 13C-NMR to probe the dynamics of the decarboxylation reaction of pyruvate via H2O2, commonly used to produce hyperpolarized bicarbonate. Using this method we are able to observe and quantify the dynamics of the intermediate state, 2-hydroperoxy-2-hydroxypropranoate, which has never before been directly observed at room temperature, as well as characterizing a previously overlooked side reaction between the products and reactants of the decarboxylation reaction. This study serves as a template for how to use hyperpolarized 13C NMR to study the dynamics of innumerable other organic reactions with polarizable substrates.

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