Upregulated glucose uptake in cancer is often observed and can be monitored with a radiolabeled analogue of glucose, 18FDG, with detection by PET, however, a well-known constraint is its ionizing radiation. Additionally, except for the trapping of that glucose analogue, PET does not provide information about subsequent glucose metabolism. Here, we demonstrated the feasibility of a simple glucose infusion protocol that allows detection of glucose oxidation in human breast cancer in vivo via 7T 13C MRS. The [U-13C]glucose infusion is performed outside of the magnet making the protocol significantly more suitable for patients compared to previous approaches that required prolonged 13C substrate infusions inside the scanner.
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