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Abstract #2945

Localized, indirect 1H-[13C] MRS measurement of glutamate and glutamine 13C-labeling in frontal cortex of human brain at 4 Tesla.

Henk M. De Feyter1, Raimund M. Herzog2, Peter B. Brown 1, Douglas L. Rothman1, and Robin A. de Graaf1

1Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, 2Department of Endocrinology, Yale University, New Haven, CT, United States

We present an indirect 1H-[13C] MRS detection method (selective proton-observed, carbon edited (selPOCE) that can be used in the frontal lobe of human brain, allows for separation of overlapping glutamate (Glu) and glutamine (Gln) peaks and provides well-defined spatial localization of the 13C-signal. The method was successfully implemented at 4 Tesla and allowed for the selective detection of 13C-labeling in Glu and Gln in a timely manner (15 min), indicating that the selPOCE can be used for quantitative studies of brain energy metabolism and neurotransmission in a relatively small volume localized in the human frontal lobe.

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