Abstract #2945

Localized, indirect 1H-[13C] MRS measurement of glutamate and glutamine 13C-labeling in frontal cortex of human brain at 4 Tesla.

Henk M. De Feyter¹, Raimund M. Herzog², Peter B. Brown ¹, Douglas L. Rothman¹, and Robin A. de Graaf¹

¹Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, ²Department of Endocrinology, Yale University, New Haven, CT, United States

We present an indirect ¹H-[¹³C] MRS detection method (selective proton-observed, carbon edited (selPOCE) that can be used in the frontal lobe of human brain, allows for separation of overlapping glutamate (Glu) and glutamine (Gln) peaks and provides well-defined spatial localization of the ¹³C-signal. The method was successfully implemented at 4 Tesla and allowed for the selective detection of¹³C-labeling in Glu and Gln in a timely manner (15 min), indicating that the selPOCE can be used for quantitative studies of brain energy metabolism and neurotransmission in a relatively small volume localized in the human frontal lobe.

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