Abstract #2948

Investigation of Lithium Distribution in the Rat Brain ex vivo using Lithium-7 Magnetic Resonance Imaging at 17 Tesla

Anne-Sophie Hanak¹, Jacques Andrew Stout², Lucie Chevillard¹, Boucif Djemaï², Patricia Risède¹, Michel Luong², Eric Giacomini², Joel Poupon³, David André Barrière^2,4, Frank Bellivier^1,5, Bruno Mégarbane^1,5, and Fawzi Boumezbeur²

¹INSERM UMR-S 1144, Universités Paris-Descartes & Paris-Diderot, Paris, France, ²Neurospin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France, ³APHP, GH Saint-Louis-Lariboisière-Fernand Widal, Laboratoire de Toxicologie biologique, Paris, France, ⁴Inserm UMR-S 894, Université Paris-Descartes, Paris, France, ⁵APHP, GH Saint-Louis-Lariboisière-Fernand Widal, Réanimation Médicale et Toxicologique, Paris, France

Lithium (Li) is the first-line mood stabilizer to treat bipolar disorder patients. However, its mechanisms of action and transport across the blood-brain barrier remain poorly understood. In this study, we aimed at mapping ex vivo the cerebral Li distribution of rats treated for 28 days with Li₂CO₃ using ⁷Li-MRI at 17.2 Tesla. Using a phantom replacement approach, MRI-derived Li concentrations were calculated and validated by comparison to inductively coupled plasma-mass spectrometry (ICP-MS) measurements. Lithium distributions were uneven (normalized lithium content ranging from 0.7 to 1.4) and symmetrical with consistently lower concentrations in the metencephalon and higher ones in the cortex.

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