Abstract #2949

Density-Adapted k-Space Sampling Technique for Fast Relaxing Chlorine-35 Nuclei at 9.4 T

Ruomin Hu¹, Andreas Neubauer¹, Matthias Malzacher¹, Simon Konstandin², and Lothar R. Schad¹

¹Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany, ²MR-Imaging and Spectroscopy, Universty of Bremen, Bremen, Germany

Chloride Cl^- as the most abundant anion in mammals is a vital component of biophysical regulatory processes. ³⁵Cl MRI has the potential to visualise Cl^- homeostatic changes during stroke, in tumors and in ionic regulatory diseases. This study aimed at demonstrating the advantages of implementing density-adapted k-space sampling to overcome the instrinsically low SNR associated with ³⁵Cl MRI. We showed that density-adapted k-space sampling yielded distinctively visible improvement of image quality as well as quantitative SNR gain in phantoms with very fast bi-exponential T₂* relaxation over conventional radial sampling.

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