Chloride Cl- as the most abundant anion in mammals is a vital component of biophysical regulatory processes. 35Cl MRI has the potential to visualise Cl- homeostatic changes during stroke, in tumors and in ionic regulatory diseases. This study aimed at demonstrating the advantages of implementing density-adapted k-space sampling to overcome the instrinsically low SNR associated with 35Cl MRI. We showed that density-adapted k-space sampling yielded distinctively visible improvement of image quality as well as quantitative SNR gain in phantoms with very fast bi-exponential T2* relaxation over conventional radial sampling.
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