Abstract #2951

High Resolution Dynamic 31P-MRSI of Ischemia-Reperfusion in Rat Hindlimb at 9.4T Using SPICE

Yuchi Liu^1,2, Bryan Alexander Clifford^3,4, Chao Ma^3,5,6, Fan Lam³, Zhi-Pei Liang^3,4, and Xin Yu^1,2,7,8

¹Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, United States, ³Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵Gordon Center for Medical Imaging, NMMI, Department of Radiology, Massachusetts General Hospital, MA, United States, ⁶Department of Radiology, Harvard Medical School, MA, United States, ⁷Department of Radiology, Case Western Reserve University, Cleveland, OH, United States, ⁸Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States

Dynamic ³¹P-MRSI serves as a non-invasive tool to assess mitochondrial oxidative capacity in skeletal muscle during ischemia-reperfusion or exercise-recovery. However, ³¹P-MRSI with high spatial resolution requires long acquisition times which render dynamic measurements impractical. In this study, we adapted a recently proposed low-rank tensor-based method for high-resolution dynamic ³¹P-MRSI in preclinical studies. We present results from an in vivo ischemia-reperfusion experiment on a rat hindlimb with 15 s nominal temporal resolution and 0.75×0.75×1.6 mm³ nominal spatial resolution, demonstrating the potential of the method for assessing mitochondrial function in different muscle types in small animal models.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.