Abstract #2952

Dynamic Oxygen-17 MR Imaging with Golden-Ratio-Based Radial Sampling and k-Space-Weighted Image Reconstruction

Yuchi Liu^1,2, Yifan Zhang^1,2, Chunying Wu², Junqing Zhu², Charlie Yi Wang^1,2, Nicholas Tomko³, Mikhail Linetsky³, Robert Salomon³, Yanming Wang^2,4, and Xin Yu^1,2,4,5

¹Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, United States, ³Department of Chemistry, Case Western Reserve University, Cleveland, OH, United States, ⁴Department of Radiology, Case Western Reserve University, Cleveland, OH, United States, ⁵Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States

This study aimed at developing a 3D dynamic oxygen-17 (¹⁷O) MR imaging method to delineate the kinetics of ¹⁷O-water uptake and washout in mouse brain with glioblastoma at high temporal and spatial resolution. A 3D imaging method using a stack-of-stars golden-ratio-based radial sampling scheme was combined with k-space weighted image reconstruction to improve the temporal resolution with preserved spatial resolution. The proposed method achieved a temporal resolution of 7.56 s with a voxel size of 5.625 μL in mouse brain at 9.4T. It can also be used to image cerebral oxygen consumption rate in ¹⁷O inhalation studies.

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