Abstract #2954

Quantification of Cerebral Metabolic Rates of 17O-Labeled Glucose in Mouse Brain with Dynamic 17O-MRS

Robert Borowiak^1,2,3, Wilfried Reichardt^1,2,3, Dmitry Kurzhunov¹, Christian Schuch⁴, Benjamin Görling⁵, Dieter Leibfritz⁶, Jochen Leupold¹, Thomas Lange¹, Helge Haas⁷, Jens Timmer⁷, and Michael Bock¹

¹Dept. of Radiology, Medical Physics, Medical Center-University of Freiburg, Germany, Freiburg, Germany, ²German Cancer Consortium (DKTK), Heidelberg, Germany, Heidelberg, Germany, ³German Cancer Research Center (DKFZ), Heidelberg, Germany, Heidelberg, Germany, ⁴NUKEM Isotopes Imaging GmbH, ⁵Bruker BioSpin GmbH, ⁶Faculty of Medicine, University of Tübingen, Germany, ⁷Institute of Physics, University of Freiburg, Germany

We studied the chemical exchange kinetics of ¹⁷O-labeled glucose at the C1 and the C6 position with dynamic ¹⁷O-MRS. A profile likelihood analysis is performed to determine identifiability and confidence intervals of the metabolic rate CMR_Glc. The exchange experiments confirm that the C6-¹⁷OH label is transferred via glycolysis exclusively by the enzyme enolase into the metabolic end product H₂¹⁷O, while C1-¹⁷OH ends up in water via direct hydrolysis as well as via glycolysis. From H₂¹⁷O-concentration time-courses cerebral metabolic rates of CMR_Glc = 0.05‑0.08 µmol/g/min are obtained which are in of the same order of magnitude as ¹⁸F-FDG PET.

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