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Abstract #2954

Quantification of Cerebral Metabolic Rates of 17O-Labeled Glucose in Mouse Brain with Dynamic 17O-MRS

Robert Borowiak1,2,3, Wilfried Reichardt1,2,3, Dmitry Kurzhunov1, Christian Schuch4, Benjamin Görling5, Dieter Leibfritz6, Jochen Leupold1, Thomas Lange1, Helge Haas7, Jens Timmer7, and Michael Bock1

1Dept. of Radiology, Medical Physics, Medical Center-University of Freiburg, Germany, Freiburg, Germany, 2German Cancer Consortium (DKTK), Heidelberg, Germany, Heidelberg, Germany, 3German Cancer Research Center (DKFZ), Heidelberg, Germany, Heidelberg, Germany, 4NUKEM Isotopes Imaging GmbH, 5Bruker BioSpin GmbH, 6Faculty of Medicine, University of Tübingen, Germany, 7Institute of Physics, University of Freiburg, Germany

We studied the chemical exchange kinetics of 17O-labeled glucose at the C1 and the C6 position with dynamic 17O-MRS. A profile likelihood analysis is performed to determine identifiability and confidence intervals of the metabolic rate CMRGlc. The exchange experiments confirm that the C6-17OH label is transferred via glycolysis exclusively by the enzyme enolase into the metabolic end product H217O, while C1-17OH ends up in water via direct hydrolysis as well as via glycolysis. From H217O-concentration time-courses cerebral metabolic rates of CMRGlc = 0.05‑0.08 µmol/g/min are obtained which are in of the same order of magnitude as 18F-FDG PET.

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