A dynamic 17O-MRI inhalation experiment enables localized mapping of the cerebral metabolic rate of oxygen consumption (CMRO2) in the human brain via H217O quantification. These functional information are tissue viability parameters and can help studying the brain metabolism. In 17O-MRI, accurate quantification and CMRO2-determination is severely biased by partial volume effects caused by low spatial resolution and fast transverse relaxation. A human brain-simulation providing realistic dynamic 17O-data was used to evaluate the performance of a partial volume correction algorithm at different temporal resolution. Findings were then adapted to an in-vivo 17O-MRI inhalation experiment which was conducted in a healthy volunteer.