Meeting Banner
Abstract #2955

Direct Partial Volume Corrected CMRO2 Determination: Simulation assisted Dynamic 17O-MRI

Sebastian C. Niesporek1, Reiner Umathum1, Jonathan M. Lommen1, and Armin M. Nagel1,2

1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Institute of Radiology, University Hospital Erlangen, Erlangen, Germany

A dynamic 17O-MRI inhalation experiment enables localized mapping of the cerebral metabolic rate of oxygen consumption (CMRO2) in the human brain via H217O quantification. These functional information are tissue viability parameters and can help studying the brain metabolism. In 17O-MRI, accurate quantification and CMRO2-determination is severely biased by partial volume effects caused by low spatial resolution and fast transverse relaxation. A human brain-simulation providing realistic dynamic 17O-data was used to evaluate the performance of a partial volume correction algorithm at different temporal resolution. Findings were then adapted to an in-vivo 17O-MRI inhalation experiment which was conducted in a healthy volunteer.

This abstract and the presentation materials are available to members only; a login is required.

Join Here