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Abstract #2956

Proof of concept for the separation of free and bound sodium in human brain through two-TE acquisitions at 3T

Yongxian Qian1, Tiejun Zhao2, Karthik Lakshmanan1, Yulin Ge1, Yvonne Lui1, Timothy Shepherd1, and Fernando E. Boada1

1Radiology, New York University, New York, NY, United States, 2Siemens Medical Solutions USA, New York, NY, United States

In human brain, intracellular sodium ions (Na+) are in slow and restricted motion due to their binding to negatively-charged macromolecules while their extracellular counterparts are in fast and unrestricted motion. This difference in motion properties leads to changes in bi-exponential transverse decay of free and bound sodium ions, which have been explored previously as a means to separate free and bound sodium. In this study, a new approach is proposed to separate free and bound sodium using single-quantum sodium images, without the SNR and SAR limitations as encountered in the triple-quantum filtering approach.

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