In human brain, intracellular sodium ions (Na+) are in slow and restricted motion due to their binding to negatively-charged macromolecules while their extracellular counterparts are in fast and unrestricted motion. This difference in motion properties leads to changes in bi-exponential transverse decay of free and bound sodium ions, which have been explored previously as a means to separate free and bound sodium. In this study, a new approach is proposed to separate free and bound sodium using single-quantum sodium images, without the SNR and SAR limitations as encountered in the triple-quantum filtering approach.
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