As the recent rapid development of radiation therapy techniques glowingly facilitate an individualized adaptive radiation therapy (RT), the roles of imaging as a tool to assess the early treatment response to RT or to tailor the treatment volume are becoming important. Conventional structural MR images have limited specificities in delineating and differentiating between residual/recurrent tumor and treatment effects (e.g., edema, inflammation, and radiation necrosis). This work presents a pilot study to assess response to RT in soft tissue sarcoma (STS) patients using a recently proposed rapid high-resolution MRSI method: SPectroscopic Imaging by exploiting spatiospectral CorrElation (SPICE).
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