Multiple sclerosis (MS) is an autoimmune disease that damages the central nervous system and affects an estimated 2.3 million people worldwide. One potential key to understanding MS is investigating the metabolic distinctions between its relapsing-remitting (RR-MS) and progressive courses (P-MS). We obtained single-voxel metabolic 1H spectra at 7 Tesla from the frontal cortex of RR-MS and P-MS patients and controls to explore the effects of disease state on concentrations of brain metabolites like glutathione, GABA, glutamate, and N-acetyl aspartate (NAA). Our results suggest an age- and disease-related decrease in glutamate, as well as a disease-related decrease in NAA, in patients with P-MS relative to RR-MS and controls without MS. No disease-related changes in GSH or GABA were found. Our data underscore the importance of continued investigation into the potential physiological distinctions among various MS subtypes.