Abstract #2972

Longitudinal evaluation of neurochemical modulation induced by quadripulse stimulation (QPS) using ultra-short TE STEAM MRS

Hitoshi Kubo^1,2, Takenobu Murakami^2,3, Masafumi Harada^2,4, Noboru Oriuchi², Seiichi Takenoshita², Shoji Yabuki¹, and Yoshikazu Ugawa^2,3

¹Preparing Section for New Faculty of Medical Science, Fukushima Medical University, Fukushima, Japan, ²Advanced Clinical Research Center, Fukushima Medical University, Fukushima, Japan, ³Department of Neurology, Fukushima Medical University, Fukushima, Japan, ⁴Department of Radiology, The University of Tokushima Graduate School, Tokushima, Japan

To evaluate longitudinal neurochemical modulation induced by rTMS, we used ultra-short TE STEAM MRS. Glx, GABA and 15 other metabolites were measured using 3T MR equipment longitudinally and LCModel was used to calculate these concentrations quantitatively. QPS was employed as rTMS and left M1 was stimulated in each subject. Five healthy male volunteers participated in this study. The long-term depression intervention induced Glx increment, and the long-term potentiation intervention induced GABA decrement. The present results suggested a usefulness of the ultra-short TE STEAM MRS in evaluation of the longitudinal neurochemical modulation induced by rTMS.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.