Abstract #2973

Effect of psychotherapeutic approaches on cortical and striatal neurochemical profile in a juvenile rat model of ADHD: an in vivo 1H MRS study @ 11.7T

Alireza Abaei¹, Francesca Rizzo^2,3, Dinesh K Deelchand⁴, Tobias M. Böckers², and Volker Rasche¹

¹Core Facility Small Animal Imaging, Ulm University, Ulm, Germany, ²Institute of Anatomy and Cell Biology, Ulm University, Ulm, Germany, ³Department of Child and Adolescent Psychiatry, Ulm University, Ulm, Germany, ⁴Center for Magnetic Resonance Research, University of Minnesota, MN, United States

Proton MRS is employed to assess the effect of systemic administration of aripiprazole and riluzole on the neurochemical profile of distinct functional regions in juvenile rat brain non-invasively in vivo. In this study, a dedicated optimized STEAM sequence with single-shot phase and frequency correction, and image-based shimming was applied to quantify subtle changes in the brain metabolites concentration during drug treatment in an ADHD rat model.

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