Cancer-associated mutations
in IDH results in overproduction of 2-hydroxyglutarate (2HG). A few studies
have evaluated the use of MR spectroscopy (MRS) technology to noninvasively
determine IDH mutation status by measuring 2HG concentrations. However, it is
unknown how factors such as signal-to-noise ratio (SNR), spectral apodization,
and Cramér–Rao Lower Bounds (CRLB) can influence MRS sensitivity and
specificity for 2HG detection in gliomas. This study seeks to define the ideal
method to define optimal thresholds of CRLB and spectral filtering resulting in
improved 2HG detection sensitivity without a drop in MRS specificity.
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