This study followed early stage schizophrenia patients undergoing treatment with single voxel MRS in the frontal lobe. Patients were split into a placebo (sugar pills) and treatment (N-acetylcysteine (NAC)) group and followed over the course of a year where they participated in 2-3 MRS scans at regular intervals. Patients show significantly elevated concentrations of Cre and Glx when compared to controls. This significance remained throughout the longitudinal study in intra- and inter-patient comparisons. This unchanged elevation of Glx and Cre contradicts the hypothesis that NAC will work to normalize these metabolite concentrations.
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