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Abstract #2976

Longitudinal MRS Study following Treatment of Early-Phase Psychosis with N-Acetylcysteine

Andrew M Wright1, Ruoyun Ma2, Tom Hummer3, Michael Francis3, Andrew Visco3, Nikki Mehdiyoun3, Ulrike Dydak2,4, and Alan Breier3

1Health Sciences, Purdue University, Lafayette, IN, United States, 2Purdue University; Indiana University School of Medicine, 3Indiana University School of Medicine, 4Health Sciences, Purdue University; Indiana University School of Medicine, Lafayette, IN, United States

This study followed early stage schizophrenia patients undergoing treatment with single voxel MRS in the frontal lobe. Patients were split into a placebo (sugar pills) and treatment (N-acetylcysteine (NAC)) group and followed over the course of a year where they participated in 2-3 MRS scans at regular intervals. Patients show significantly elevated concentrations of Cre and Glx when compared to controls. This significance remained throughout the longitudinal study in intra- and inter-patient comparisons. This unchanged elevation of Glx and Cre contradicts the hypothesis that NAC will work to normalize these metabolite concentrations.

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