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Abstract #2984

Metabolic Subtypes of Atypical Teratoid Rhabdoid Tumors

Benita Tamrazi1, Marvin D Nelson1, and Stefan Bluml1

1Radiology, Children's Hospital Los Angeles, Los Angeles, CA, United States

Atypical Teratoid Rhabdoid Tumors (AT/RT) are highly malignant pediatric brain tumors distinguished from other primitive/embryonal tumors by alterations of the SMARCB1 gene. Recently, two molecular subtypes have been described for AT/RTs. We have reviewed MR spectra of AT/RT patients and identified two distinct clusters in respect to their metabolic profiles. Should a correlation with genetic subtypes be confirmed, in vivo MRS could potentially play a key role in the initial stratification of patients diagnosed with AT/RT.

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