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Abstract #2987

Investigating metabolic alterations in a depressive-like rat model of chronic forced swimming stress using in vivo proton magnetic resonance spectroscopy at 7T

Chi-Hyeon Yoo1,2, Kyu-Ho Song1, Song-I Lim1,2, Do-Wan Lee3, Dong-Cheol Woo2, and Bo-Young Choe1

1Department of Biomedical Engineering, and Research Institute of Biomedical Engineering, The Catholic University of Korea College of Medicine, Seoul, Korea, Republic of, 2Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of, 3Ehwa Brain Institute, Ehwa Woman's University, Seoul, Korea, Republic of

The chronic forced swimming stress (CFSS) depression-like animal model has been widely used to investigate the pathophysiology of depression focusing on the monoamine system. The goal of this study was to investigate the CFSS-induced metabolic effects in the prefrontal cortex (PFC) of animals showing depression-like behavior using high-field and short echo time (TE) in vivo proton magnetic resonance spectroscopy (1H MRS). The results suggest that high-field and short TE in vivo 1H MRS can reliably quantify the key metabolites involved in depression and CFSS-induced behavioral despair and metabolic alterations similar to those found in human patients with depressive disorders.

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