Abstract #2987

Investigating metabolic alterations in a depressive-like rat model of chronic forced swimming stress using in vivo proton magnetic resonance spectroscopy at 7T

Chi-Hyeon Yoo^1,2, Kyu-Ho Song¹, Song-I Lim^1,2, Do-Wan Lee³, Dong-Cheol Woo², and Bo-Young Choe¹

¹Department of Biomedical Engineering, and Research Institute of Biomedical Engineering, The Catholic University of Korea College of Medicine, Seoul, Korea, Republic of, ²Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of, ³Ehwa Brain Institute, Ehwa Woman's University, Seoul, Korea, Republic of

The chronic forced swimming stress (CFSS) depression-like animal model has been widely used to investigate the pathophysiology of depression focusing on the monoamine system. The goal of this study was to investigate the CFSS-induced metabolic effects in the prefrontal cortex (PFC) of animals showing depression-like behavior using high-field and short echo time (TE) in vivo proton magnetic resonance spectroscopy (1H MRS). The results suggest that high-field and short TE in vivo 1H MRS can reliably quantify the key metabolites involved in depression and CFSS-induced behavioral despair and metabolic alterations similar to those found in human patients with depressive disorders.

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