Meeting Banner
Abstract #2988

Metabolic Assessment of a Migraine Model using Relaxation-Enhanced 1H Spectroscopy at Ultra-High Field

Nastaren Abad1,2, Jens T. Rosenberg1, Tangi Roussel3, Dillon Grice2, Michael G. Harrington4, and Samuel Colles Grant1,2

1Center for Interdisciplinary Magnetic Resonance, National High Magnetic Field Laboratory, Tallahassee, FL, United States, 2Chemical & Biomedical Engineering, Florida State University, Tallahassee, FL, United States, 3Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel, 4Molecular Neurology Program, Huntington Medical Research Institutes, Pasadena, CA, United States

This study evaluates biochemical and metabolic imbalances that may result in a collection of dysfunctional pathways that are distinct in migraineurs. The high sensitivity and spectral dispersion available to 1H MRS at 21.1 T expanded metabolic profiling in an animal model of migraine to include total creatine (tCr), choline (Cho), N-acetyl-aspartate (NAA), myoinositol (mI), lactate (Lac), taurine (Tau), aspartate (Asp), Glx, a mixture of glutamate, glutamine and GABA, and Gly, the latter identified as a mixture of glycine, glutamine, and glutamate. For the migraine analogue, Lac, Gly and Tau increased while tCr decreased temporally and in comparison to saline controls.

This abstract and the presentation materials are available to members only; a login is required.

Join Here