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Abstract #2990

Integrative analysis of GABA-edited MRS data acquired at 19 research sites

Mark Mikkelsen1,2, Maiken K. Brix3,4, Pieter F. Buur5, Kim M. Cecil6, Kimberly L. Chan1,2,7, David Y.-T. Chen8, Alexander R. Craven9,10, Koen Cuypers11,12, Niall W. Duncan13, Ulrike Dydak14, David A. Edmondson14, Gabriele Ende15, Lars Ersland10,16, Ian Greenhouse17, Ashley D. Harris18, Stefanie Heba19, Tun-Wei Hsu20, Jacobus F. A. Jansen21, R. Marc Lebel22, Chien-Yuan E. Lin23, Jy-Kang Liou20, Jiing-Feng Lirng20, Ruoyun Ma14, Celine Maes11, Scott O. Murray24, Sean Noah17, Ralph Noeske25, Michael D. Noseworthy26, Georg Oeltzschner1,2, James J. Prisciandaro27, Nicolaas A. J. Puts1,2, Timothy P. L. Roberts28, Markus Sack15, Napapon Sailasuta29,30, Muhammad G. Saleh1,2, Michael-Paul Schallmo24, Nicholas Simard31, Stephan P. Swinnen11,32, Martin Tegenthoff19, Peter Truong29, Hans-Jörg Wittsack33, Vadim Zipunnikov34, Helge J. Zöllner33,35, and Richard A. E. Edden1,2

1Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Radiology, Haukeland University Hospital, Bergen, Norway, 4Department of Clinical Medicine, University of Bergen, Bergen, Norway, 5Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, 6Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 7Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 8Department of Radiology, Taipei Medical University Shuang Ho Hospital, New Taipei City, Taiwan, 9Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway, 10NORMENT – Norwegian Center for Mental Disorders Research, University of Bergen, Bergen, Norway, 11Department of Kinesiology, KU Leuven, Leuven, Belgium, 12REVAL Rehabilitation Research Center, Hasselt University, Diepenbeek, Belgium, 13Brain and Consciousness Research Centre, Taipei Medical University, Taipei, Taiwan, 14School of Health Sciences, Purdue University, West Lafayette, IN, United States, 15Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany, 16Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway, 17Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, United States, 18Department of Radiology, University of Calgary, Calgary, AB, Canada, 19Department of Neurology, BG University Hospital Bergmannsheil, Bochum, Germany, 20Department of Radiology, Taipei Veterans General Hospital, National Yang-Ming University School of Medicine, Taipei, Taiwan, 21Department of Radiology, Maastricht University Medical Center, Maastricht, Netherlands, 22GE Healthcare, Calgary, AB, Canada, 23GE Healthcare, Taipei, Taiwan, 24Department of Psychology, University of Washington, Seattle, WA, United States, 25GE Healthcare, Berlin, Germany, 26Department of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada, 27Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States, 28Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, 29Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada, 30Department of Psychology, University of Toronto, Toronto, ON, Canada, 31School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada, 32Leuven Research Institute for Neuroscience & Disease (LIND), KU Leuven, Leuven, Belgium, 33Department of Diagnostic and Interventional Radiology, University Düsseldorf, Düsseldorf, Germany, 34Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States, 35Institute of Clinical Neuroscience and Medical Psychology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany

In this large multi-vendor, multi-site study, we seek to better understand the factors that impact quantitative outcomes of GABA-edited MR spectroscopy. Data from 187 participants from 19 research sites acquired on scanners from the three major vendors were pooled and analyzed using a standard pipeline. Coefficients of variation for GABA measurements acquired on each scanner platform and across the entire cohort were less than 11%. Multilevel linear modelling showed that most of the variance was accounted for by participant-level differences, while vendor-level differences accounted for comparatively more proportional variance than site-level differences.

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