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Abstract #2992

Basis set optimization for quantification of semi-LASER at 9.4T under consideration of CP effect and relaxation

Ioannis-Angelos Giapitzakis1,2 and Anke Henning1,3

1High Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2Graduate School of Neural and Behavioural Sciences, Tuebingen, Germany, 3Institute of Physics, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany

In this abstract, we evaluated the Carr-Purcell behavior of semi-LASER sequence at 9.4T and we studied the influence of different relaxation times between the different moieties of NAA and NAAG using in-vivo acquired from occipital lobe and simulated spectra. The results indicate that differences in the relaxation time between different moieties can affect the fitting results and the metabolites levels. Moreover, an estimated value for the relaxation time of NAA-aspartate moiety is given. This work indicates that more measurements and investigation should be done, studying more metabolites and brain regions.

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