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Abstract #2996

Tissue-type dependence of in vivo chemical shifts of metabolites ?

Jan Willem van der Veen1, Stefano Marenco2, Karen Berman3, and Jun Shen1

1Magnetic Resonance Spectroscopy Core, NIH, NIMH, Bethesda, MD, United States, 2NIMH-IRP, 3Clinical & Translational Neuroscience Branch, NIH, NIMH

Recent high field susceptibility imaging experiments have revealed significant differences in water frequency in different tissue types. We studied the frequency distribution of choline, creatine, NAA, myo-inositol, glutamate, glutamine and GABA from gray matter- and white matter-dominant voxels. Based on data acquired from 135 normal subjects it was found that the best fit frequency of at least several metabolites are significantly dependent on tissue type composition.

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