Meeting Banner
Abstract #2997

Difference optimization: Automatic correction of relative frequency and phase for 1H MEGA-PRESS spectra

Marianne Cleve1, Martin Krämer1, Alexander Gussew1, and Jürgen R. Reichenbach1

1Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany

We present an automatic routine for alignment of GABA 1H MEGA-PRESS spectra to reduce subtraction artefacts which can compromise reliable GABA quantitation. The algorithm iteratively optimizes relative frequency and phase offsets between the edited and non-edited 1H MEGA-PRESS spectra by minimizing the sum of the magnitude of the difference spectrum. The proposed method was applied to simulated spectra with preset frequency and phase errors and in vivo MEGA-PRESS data and compared to spectral registration, an alignment method implemented in the open source FID-A toolbox1. Difference optimization demonstrated robust performance without requiring limitation of the input data range or user intervention.

This abstract and the presentation materials are available to members only; a login is required.

Join Here