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Abstract #2998

Pinpointing differences in diffusion characteristics of metabolites determined in human gray matter using simultaneous spectral and diffusion modeling

Andre Doering1, Victor J Adalid Lopez1, Chris Boesch1, and Roland Kreis1

1Depts. Radiology and Clinical Research, University Bern, Bern, Switzerland, CH-3010, Switzerland

A recently described non-water suppressed diffusion-weighting MR spectroscopy sequence was applied in 13 healthy volunteers. The method uses the large water signal to compensate motion-related signal drop for the metabolite signals. 2D signal modeling with FiTAID allows for implementation of different prior knowledge constraints in order to prevent non-physical solutions or to restrict the number of unknown diffusion constants. In gray matter, highly significant differences for ADCs of several metabolites (faster diffusion for glutamate than NAA or myo-inositol) were found and their dependence on prior knowledge constraints investigated.

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