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Abstract #3007

Temperature Calibration and Errors Assessed by Magnetic Resonance Spectroscopy

Bhanu Prakash KN1, Sanjay K Verma2, Suresh Sadananthan3, Venkatesh Gopalan2, Jadegoud Yaligar2, Sankar Seramani2, Andrew A Maudsley4, and Sendhil Velan S2

1Signal and Image Processing, Singapore Bioimaging Consortium, Singapore, Singapore, 2Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore, 3Singapore Institute for Clinical Sciences, Singapore, 4Miller School of Medicine, University of Miami, Miami, FL, United States

Whole brain temperature mapping is of great interest for investigating traumatic brain injuries. Single-voxel-spectroscopy (SVS) and CSI approaches provides limited spatial coverage in the brain, whereas 3D Echo-planar spectroscopic imaging (EPSI), covers the entire brain for investigating temperature and metabolism in traumatic brain injury and other studies . Our study focuses on calibration and validation of the temperature measurement in brain phantoms using EPSI and SVS at pre-clinical and clinical scanners, to study and analysis of whole brain temperature in rodents and humans.

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