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Abstract #3008

Effect of dietary intervention on liver fat content during the day. A pilot MR study

Miloslav Drobny1, Petr Sedivy1, Tereza Blahova2, Katerina Zemankova2, Monika Dezortova1, Jan Kovar2, and Milan Hajek1

1MR Unit, Dept Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 2Centrum of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

Liver fat content is an important parameter characterizing clinical status of the liver. Steatosis can be measured by magnetic resonance spectroscopy and imaging techniques non-invasively. The group of healthy volunteers was examined by MRS and MRI on three occasions after fat load, fat load with glucose and during whole-day fasting.

Obtained results show that both used MR techniques are suitable for fat content measurements in the liver during dietary intervention. The pilot study results suggest that concentration of NEFA in systemic circulation is a critical factor that determines whether fat accumulates in the liver during the day in healthy insulin sensitive subjects.

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