For the detection and quantification of lactate (Lac) and β-hydroxybutyrate (bHB) via 1H-MRS, difference editing methods such as MEGA-PRESS have been proposed. Since MEGA-PRESS suffers from substantial signal loss due to large chemical shift displacement, we propose MEGA-sLASER for simultaneous detection of the two metabolites at 3T. It is demonstrated that the signal-to-noise ratio of the target resonances in the difference spectrum is increased by a factor of two compared to MEGA-PRESS and that quantification accuracy can thus be substantially improved, enabling the robust detection of Lac and bHB in healthy brain.
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