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Abstract #3010

Improved Triple-refocusing 1H MRS at 3T for detection of GABA and Glutamate in human brain in vivo

Zhongxu An1, Vivek Tiwari1, Sandeep Ganji1, and Changho Choi1

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States

Reliable detection of GABA is important for studies in neuro-psychiatric diseases. In vivo 1H GABA resonances are extensively overlapped with the neighboring resonances including glutamate and glutamine. We present a new triple-focusing 1H MRS method which can fully resolve GABA 2.29-ppm and Glu 2.35 ppm signals at 3T.

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