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Abstract #3016

Simultaneous measurement of Aspartate, NAA, and NAAG using HERMES spectral editing at 3 Tesla

Kimberly Chan1,2,3, Muhammad Saleh2,3, Georg Oeltzschner2,3, Peter Barker2,3, and Richard Edden2,3

1Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, United States, 2Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, United States, 3F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

It has previously been shown that the HERMES method (‘Hadamard Encoding and Reconstruction of MEGA-Edited Spectroscopy’) can be used to simultaneously edit two metabolites (1). Examples of pairs of metabolites edited include N-acetyl-aspartate (NAA) and N-acetyl aspartyl glutamate (NAAG), or glutathione and GABA (2). Here, we demonstrate that HERMES can acquire simultaneously and then separate three overlapping edited signals, for the example of NAA, NAAG and Aspartate (Asp). We optimize this sequence using simulations, and show its feasibility in phantoms and in vivo. We also explore the echo time modulation of the aspartate spin system using simulations and phantom experiments.

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